Hepatitis B is a liver problem and is a relatively dangerous problem for patients, because it is likely to cause liver function problems. Hepatitis B is transmitted in certain ways, such as blood transmission, mother-to-child transmission, medical transmission, and sexual transmission, so if your husband has hepatitis B, female friends must pay attention! 1. What is Xiao San Yang The so-called "small three positives" refers to the immunological indicators of hepatitis B virus in patients with chronic hepatitis B or hepatitis B virus carriers: hepatitis B surface antigen (HBsAg), hepatitis B e antibody (HBeAb), and hepatitis B core antibody (anti-HBC). The difference between them and "big three positives" is that big three positives are e antigen positive and e antibody negative, while "small three positives" are e antigen negative and e antibody positive. There are two types of "small three positive" patients, one is virus negative small three positive, and the other is virus positive small three positive. Some people often think that big three positive is serious but small three positive is okay. In fact, this is a misunderstanding. The harm of virus positive small three positives is increasingly valued by liver disease professionals. 2. The transmission routes of small three positive are 1. Transmission through blood. Transfusion of very small amounts of blood or blood products infected by patients with hepatitis B virus (HBV) can cause post-transfusion hepatitis B. 2. Mother-to-child transmission. This is the main transmission route of hepatitis B virus. 3. Nosocomial transmission: Infection occurs when medical instruments contaminated with HBV are used repeatedly without strict disinfection during examination and treatment in hospitals. 4. Sexual transmission. Sexual behavior between husband and wife is one of the causes of sexual transmission of hepatitis B virus (HBV). Condoms should be used for susceptible people. 3. Clinical significance of Xiao San Yang Since the pre-C region gene of the HBV genome is prone to mutation, which is often manifested as a G1896A mutation at the end of the pre-C region, a new stop codon (TAG) is generated, which blocks the formation of HBeAg and causes HBeAg deficiency or negative conversion. However, HBV can actually still exist or replicate in large quantities. Patients with negative serum HBeAg but high HBV DNA levels should be paid attention to. Therefore, HBeAg cannot be used as an indicator for observing the efficacy of antiviral treatment for hepatitis B. The clinical significance of hepatitis B markers varies. It is difficult to fully diagnose the disease based on a single indicator. Only by combining multiple indicators and HBN DNA test results with clinical conditions can we judge the degree of infectiousness and the severity of the disease. It is also an important indicator of the effectiveness of hepatitis B treatment. |
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