What should men check for fetal demise?

In fact, fetal growth retardation is not entirely the fault of female friends, but may also be caused by the male partner, such as chromosomal abnormalities, insufficient sperm maturity, etc. These will have a great impact on fetal growth retardation. Frequent fetal growth retardation is also very harmful to the body of female friends, so it is necessary to find out the cause in time.

1 Chromosome abnormality

Chromosomal abnormalities in both men and women may lead to fetal growth retardation. Common chromosomal abnormalities include numerical abnormalities, structural abnormalities and polymorphisms, DNA damage such as the size of the Y chromosome, the size of the skeletal body, and the growth or shortening of the secondary scar. That is, sperm with damaged sperm DNA can still fertilize, and after the sperm and egg combine, the oocyte has the ability to repair sperm DNA damage. Severe (related to the man’s age), or the oocyte repair ability is weakened, which may result in miscarriage, embryonic growth retardation or deformity. Therefore, patients with severe sperm DNA damage should actively seek the cause, quit smoking, prevent radiation, treat varicocele and other targeted treatments.

2Abnormal sperm maturity

Natural fertilization and in vitro fertilization require sperm to recognize and penetrate the mucus matrix surrounding the egg, granulosa cells and zona pellucida. Hyaluronic acid is the main component of the mucus matrix of the egg and zona pellucida. Sperm binds to the hyaluronic acid of the egg, and then penetration and fertilization are achieved. However, sperm can only acquire the ability to bind to hyaluronic acid after maturity. Immature sperm does not have the ability to bind to hyaluronic acid, resulting in fertilization failure. A reduced hyaluronic acid binding rate indicates a sperm maturation disorder and is also one of the risk factors for spontaneous abortion and embryo arrest in the female's early pregnancy.

3. Unhealthy lifestyle

Long-term excessive mental and psychological stress, irregular lifestyle, obesity, lack of exercise, smoking, alcoholism, etc. In addition, living and working environment factors also have an impact on pregnancy, such as drugs, pesticides, industrial poisons, ionizing radiation, high temperature environment, noise pollution, biological toxins, etc. For such patients, adjusting living habits and reducing mental and psychological stress can increase the success rate of pregnancy.

In a word, for couples with recurrent miscarriage, it is necessary to pay attention to the male factor and promptly complete the male's chromosome, semen routine, sperm DNA fragmentation and other tests to clarify the cause. The test specimens are male blood and semen (sexual life is prohibited for 1 week). The test fee is generally around 1,000 yuan, so as to facilitate symptomatic treatment.