The latest treatment for premature ejaculation

PDE5 inhibitors: refers to the drug tadalafil (meaning the product: Viagra), tadalafil (meaning the product Cialis): mainly used to treat ED (erectile dysfunction), and also has certain practical effects on PE (premature ejaculation). It is definitely effective, but the price is relatively expensive, there are many contraindications, it can be used occasionally, and it cannot be taken as a radical cure.

Disadvantages: (1) There are serious side effects and many contraindications (see instructions for use), which is not suitable for long-term use. (2) It is a drug for treatment, not a radical cure. The drug is effective only once. (3) It is relatively expensive and not suitable for popularization.

(2) Anti-anxiety drugs: SSIRs (hydroxytryptamine reuptake inhibitors): Common ones include paroxetine hydrochloride (product name: Paxil), fluoxetine hydrochloride (product name: Seroxetine), sertraline hydrochloride (product name: Zoloft), dapoxetine hydrochloride (product name: Priligy), etc. Their efficacy is to inhibit the reuptake of 5-5-hydroxytryptamine into the mammary neurotransmitter pores. After 5-5-hydroxytryptamine is deposited on the mammary neurotransmitter membrane, the protein kinase feedback property is reduced, the mammary nerve excitation threshold is increased, and the mammary sensitivity is reduced. Another tricyclic anti-anxiety drug, clomipramine, also has the effect of delaying ejaculation. The above drugs take effect after taking the medicine for about 7 days. According to the mean delay time of IELT (intravaginal ejaculation latency time, that is, the time from the beginning of insertion to the beginning of ejaculation), paroxetine was 8.8 times, dapoxetine was 4.7 times, clomipramine was 4.6 times, sertraline was 4.1 times, fluoxetine was 3.9 times, and placebo was 1.4 times.

Dapoxetine hydrochloride (product name: Priligy): It is the only drug developed for premature ejaculation at this stage, and the only drug approved by the China Food and Drug Administration (CFDA) for the treatment of premature ejaculation (PE). It is effective from the first dose. If taken within 1-3 hours before sexual intercourse, 30mg and 60mg can improve the patient's ejaculation control by 51% and 58% respectively. The price of 3 tablets/box is about 240 yuan.

Disadvantages: (1) Side effects are quite large, and there are many contraindications (see instructions for use), which are not suitable for long-term use. (2) Most drugs take a long time to take effect, and it takes about 7 days of continuous use to see results. (3) Drug treatment is not a radical cure. Because the decrease in neurotransmitter post-membrane protein kinase is not irreversible, the symptoms will gradually relapse after drug withdrawal, and the drug effect can only be maintained for a period of time. (3) The only drug that can take effect on the same day is dapoxetine hydrochloride. Taking 30mg and 60mg can only improve the patient's ejaculation control by 51% and 58% respectively.

2. Topical medications:

Products with topical anesthetics as the main ingredient: If you search the keywords "Tingshi external application" or "premature ejaculation external application" on Taobao, you can retrieve hundreds of pages and tens of thousands of "products". Whether they are foreign or domestic products, or Chinese and Western medicines, they are essentially the same: the effective ingredients are basically all local anesthetics. In the vast majority of products, you can see common anesthetics such as tetracaine, lidocaine, prilocaine, and benzocaine. Those with a little more technological content will be made into water-oil solvents and ointments, and those that are convenient and labor-saving will be directly configured into powders, sprays, etc.

Disadvantages: (1) There are many products without topical anesthetics. (2) For products with topical anesthetics, the numbness of the glans penis is more serious, which seriously affects pleasure. (3) Excessive use can cause numbness of the male genitals and lead to inability to get an erection. (4) It can cause local anesthesia in women, reduce pleasure, or even cause skin allergies. This can be avoided by washing before insertion or wearing a condom.