Causes of Lupus Erythematosus in Men

Lupus erythematosus is one of the autoimmune diseases and belongs to the category of connective tissue diseases. Lupus erythematosus is divided into discoid lupus erythematosus (DLE), targeted lupus erythematosus (SLE), acute cutaneous lupus erythematosus, and superficial lupus erythematosus. Lupus erythematosus has a slow onset and develops insidiously. The clinical symptoms are varied and unpredictable.

Discoid lupus erythematosus mainly affects the skin, while targeted lupus erythematosus often affects several internal organs and systems. About 70% to 85% of lupus erythematosus patients have skin manifestations, so lupus erythematosus has been the focus of dermatological research for many years. In addition, some people believe that SLE should be classified as a rheumatic disease. With people's increasing attention to lupus erythematosus, the continued development of scientific research on various aspects of lupus erythematosus will eventually have a positive impact on its diagnosis and treatment.

Since most lupus patients are women of childbearing age, the question of whether lupus is hereditary has become a matter of great concern to patients and their families. Many genetic clinical epidemiological studies have confirmed that lupus has a certain genetic tendency.

It is found that the collateral disease rate of lupus erythematosus patients is 5-12%, and the rate in heterozygous women is 23-69%, which indicates that genetic inheritance is related to the occurrence of the disease. From the perspective of genetic inheritance, there is something called human leukocyte count antigen (HLA) on the short arm of the sixth sex chromosome of humans. It is composed of a variety of genetic genes and is closely related to human genetic inheritance. HLA is divided into class I, class II, and class III genetic genes.

Studies have found that the HLA-II class molecule structure is closely related to the susceptibility gene of lupus erythematosus and the production of various autoantibodies during the development of lupus erythematosus. According to tests, the incidence of lupus erythematosus in people with HLA-DR2 and HLA-DR3 genetic genes is much higher than that in normal control groups, which also confirms the genetic tendency of this disease.

However, in clinical medicine, we have also seen that many children born to lupus patients are very healthy and do not have lupus. In fact, the cause of lupus is the result of the effects of a variety of complex factors including infection, endocrine and environmental influences. It should be emphasized that clinical medicine has found that mental factors are a very key cause of the disease and aggravation.

Therefore, it can only be said that lupus erythematosus has a genetic tendency rather than a genetic disease, so lupus erythematosus patients do not need to worry too much about their own disease genes being passed on to their children.

Lupus erythematosus disease

Lupus erythematosus is an autoimmune disease and belongs to the category of connective tissue disease. It is divided into discoid lupus erythematosus (DLE), targeted lupus erythematosus (SLE), acute cutaneous lupus erythematosus, and superficial lupus erythematosus.

Lupus erythematosus has a slow onset and develops insidiously, with a variety of clinical symptoms that are unpredictable. Discoid lupus erythematosus mainly affects the skin, while targeted lupus erythematosus often affects several internal organs and systems. About 70% to 85% of lupus erythematosus patients have skin manifestations, so lupus erythematosus has been the focus of dermatological research for many years.