(1) 0.5% podophyllotoxin tincture (or 0.15% cream) is suitable for treating genital warts with a diameter of ≤10mm, and the clinical treatment rate is about 90%. The area of the warts should not exceed 10cm2, and the total daily dosage should not exceed 0.5ml. After taking the medicine, wait for the medicine to dry naturally. The side effects are mainly local irritation, which may include itching, burning pain, swelling, erosion and necrosis. In addition, this drug has the effect of fetal malformation and is not suitable for pregnant women. (2) 5% imiquimod cream is used to treat condyloma acuminatum, and the average clearance rate of warts is 56%. The advantage of this treatment is that the recurrence rate is low, about 13%. The occurrence of erythema is not a condition for discontinuation of medication. The occurrence of erosion or damage requires discontinuation of medication and reexamination. The doctor will solve the wound and decide whether to take the medicine again. The side effects are mainly partial irritation, which may include itching, burning pain, erythema, and erosion. The safety factor of imiquimod during pregnancy has not been established, and pregnant women should not use it. (3) Treatment with 80% to 90% trichloroacetic acid or dichloroacetic acid must be performed by a doctor. When using, apply a small amount of the solution on the wart injury and wait for it to dry. At this time, a layer of white frost will appear on the surface. During treatment, pay attention to protecting the surrounding normal skin and mucous membranes. If the amount of external application solution is excessive, light calcium powder, sodium bicarbonate (baking soda) or liquid soap can be applied after application to neutralize excess and unreacted acid. This drug should not be used for warts that are too keratinized or large, multiple, or have a large total area. Side effects include local irritation, swelling, erosion, etc. Cold therapy Using -196℃ ultra-low temperature liquid nitrogen, the autoclave method is used to treat condyloma acuminatum, which promotes the necrosis of wart tissue and makes it fall off. The actual operation is simple, efficient, and easy for patients to bear. This method is suitable for warts with a small number and a small total area. It can be treated 1 to 2 times, with a time interval of one week. Laser Surgery Generally, CO2 laser is used to treat condyloma acuminatum by burning method. For small or multiple warts, one-time treatment is feasible. For multiple or large warts, 2 to 3 treatments are feasible. The time interval is generally one week. Electrocautery Use high-frequency electroacupuncture or electrosurgery to remove warts. This treatment method is suitable for warts with a small number and small area. Hydroxylevulinic acid photodynamic therapy (ALA-PDT) This method replaces the destructive power of proliferating abundant body cells, which not only has a destructive effect on the condylar warts visible to the human eye, but also can eliminate subclinical hazards and latent infected tissues. It has the advantages of high cure rate, low recurrence, few and mild side effects, and good patient compliance. |
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