What to do if male chromosome abnormalities occur?

Chromosomal abnormalities are very harmful. If a woman becomes pregnant, it is very easy to cause miscarriage, and there is a high chance that the baby will be born with Down syndrome. The key to chromosomal abnormalities is prevention, and treatment is also relatively complicated.

1. Western medicine treatment of chromosomal abnormalities

Chromosomal dysgenesis is difficult to treat and the treatment effect is unsatisfactory, so prevention is particularly important. Preventive measures include premarital examinations, genetic consultations, chromosome testing, and prenatal diagnosis. If there is a risk of giving birth to a child with the disease, selective abortion can be used to prevent the birth of the child. The prognosis of 21-trisomy syndrome with severe malformations is poor, mostly stillbirth or neonatal death. The IQ of surviving children is significantly lower than normal and they cannot take care of themselves. Therefore, if a diagnosis is made before there is a chance of survival, termination of pregnancy can be chosen.

At present, treatment is mainly symptomatic treatment and correction of organ deformities. Gene therapy, cell therapy, and replacement therapy are also developing. However, chromosomal abnormalities are difficult to treat and the treatment effect is unsatisfactory. There is no effective drug for the treatment of congenital intellectual disability caused by them. You can try Chinese medicine or rehabilitation training.

2. Prognosis

The prognosis of different types of chromosomal dysplasia varies, but most have a poor prognosis. Mental retardation and growth retardation are common features of chromosomal diseases.

2. Causes of Chromosomal Abnormalities

1. Physical factors (25%):

The radiation environment in which humans live includes natural radiation and artificial radiation. Natural radiation includes cosmic radiation, earth radiation and radiation from radioactive substances in the human body, while artificial radiation includes radioactive radiation and occupational exposure.

2. Chemical factors (15%):

People are exposed to a variety of chemicals in their daily lives, some of which are natural products and some of which are artificially synthesized. They can enter the human body through diet, breathing or skin contact and cause chromosomal aberrations.

3. Biological factors (10%):

When cells in culture are treated with viruses, various types of chromosomal aberrations are often induced, including breaks, fragmentation, and exchanges.

4. Maternal age effect (5%):

When the fetus is 6-7 months old, all oogonia have developed into primary oocytes and entered the nuclear reticulation stage from the first meiotic prophase. At this time, the chromosomes are loose and stretched again, just like the previous nucleus, and they remain until before ovulation in puberty. As the mother ages, under the influence of many factors inside and outside the mother, the egg may also undergo many aging changes, affecting the relationship between the same pair of chromosomes in the mature division and the behavior in the late division, which leads to the non-separation of chromosomes.

5. Genetic factors (5%):

Chromosomal aberrations often show a familial tendency, which suggests that the chromosomal aberration is related to genetics.

6. Autoimmune diseases (5%)

Autoimmune diseases appear to play a role in chromosomal nondisjunction, such as the close correlation between increased primary autoimmune antibodies in the thyroid gland and familial chromosomal abnormalities.