According to the developmental characteristics of the human body, the difference between men and women is that men mainly secrete androgens, while women mainly secrete estrogens. Therefore, there are different manifestations between men and women. However, sometimes there are problems with hormone secretion due to some pathological and physiological reasons. Today we are going to introduce how to treat insufficient androgen secretion. General treatment: ① Maintain a healthy lifestyle and remove risk factors: such as maintaining a good mentality and marital relationship, strengthening physical exercise, avoiding sitting for long periods of time, smoking, alcoholism and other bad living habits. ② Actively control concurrent chronic diseases: Many chronic diseases such as diabetes and coronary heart disease are factors that cause or aggravate LOH. Effective control of chronic diseases is beneficial to the recovery of LOH. 1. Testosterone supplementation therapy (1) Principle: The purpose of testosterone supplementation therapy (TST) is to maintain the physiological concentration of testosterone in the blood, maintain male sexual function, and improve the clinical symptoms of LOH. It is generally believed that TST should achieve: ① It can supplement the physiological needs of testosterone (3-10 mg/d); ② The levels of DHT and E2 corresponding to the testosterone level are within the normal physiological range; ③ Simulate the human testosterone ④ The natural rhythm of high secretion in the morning and low secretion in the evening does not inhibit the hormone secretion and spermatogenesis of the testicles; ④ There are no adverse reactions in the prostate, blood lipids, liver or respiratory function; ⑤ It is easy to use and patients are willing to accept it. However, with age, the risk of adverse reactions such as prostate disease, cardiovascular disease and erythrocytosis after testosterone supplementation increases. Therefore, for elderly men with androgen deficiency, it is more appropriate to use short-acting preparations and stop taking the medicine in time if adverse reactions are found. (2) Indications Middle-aged and elderly men with LOH clinical symptoms and decreased serum FT, TT, Bio-T, TSI and/or FTI levels (serum TT <8 nmol/L (230 ng/dl) or serum FT < 8.5 If the serum TT level is between 8 and 12 nmol/L, testosterone supplementation is recommended. If the serum TT level is between 8 and 12 nmol/L, repeat the measurement of serum TT and SHBG levels, and calculate the FT level. If the serum FT level is between 8.5 pg/ml and 11.8 pg/ml, testosterone supplementation can be performed if LOH symptoms are obvious. (3) Contraindications ① Patients with prostate cancer or breast cancer ② Patients with polycythemia ③ Patients with severe sleep apnea syndrome ④ Patients with benign prostatic hyperplasia and severe lower urinary tract obstruction ⑤ Patients with severe heart, liver or kidney failure ⑥ Patients with PSA >4 ng/ml and suspected prostate cancer The above is what we introduced today, some manifestations and treatment measures of sexual dysfunction caused by insufficient androgen secretion, which in turn affects life. It also introduces the indications and contraindications of the treatment methods. Therefore, male friends who have this problem should carefully check their symptoms and then refer to the treatment. |
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