Causes of melanin pigmentation on the glans penis

When our skin ages, it will have pigmentation. It is more obvious on the face. But for male friends, the glans penis is also prone to pigmentation. So what is the reason for the pigmentation of the glans penis? Unlike the face, the pigmentation of the glans penis is caused by frequent friction. If male friends masturbate frequently, the color of the glans penis will be darker.

Melanosis refers to skin that is brown or mouse-gray, darker than normal skin of the same race or one's own original skin color. It usually refers to systemic melanin, but is sometimes also used to refer to localized melanin. Melanosis is caused by excessive melanin production by melanocytes and excessive deposition in epidermal keratinocytes.

In daily life, melanin not only affects the appearance, but also has certain potential harm to the body. Some people do not understand melanin, which leads to complications of melanin. The reason for melanin on the face is that the human skin is constantly metabolizing various wastes every day. If the body's endocrine circulation is not smooth, pigmentation will occur. For example, if there is a wound on the body, and the body's circulation is not smooth, it is easy to cause black precipitation after the wound heals, which looks like a mole.

①. Endocrine diseases: due to excessive melanocyte stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH), such as Addison's disease, Cushing's disease, Nelson syndrome, ovarian tumors, malignant pheochromocytoma, and long-term ACTH treatment. During pregnancy, when using estrogen and estrogen-containing contraceptives, darker skin pigmentation is also more common, and melanin deposition is also common.

② Metabolic diseases: such as hemochromatosis, various types of porphyria with photosensitive dermatitis, hepatolenticular degeneration, cutaneous amyloidosis, Gaucher's disease and other symptoms of melanin deposition.

③. Nutritional diseases: Melanin deposition can cause vitamin A deficiency, vitamin B12, vitamin C, folic acid, niacin deficiency, malabsorption syndrome, etc.

④. Chronic infections: such as malaria, kala-azar, and schistosomiasis.

⑤. Tumor: Seen in tumors that produce ectopic ACTH and MSH, such as lung cancer, pancreatic cancer, advanced malignant melanoma, and advanced malignant tumors. Melanin deposition is occasionally seen in Hodgkin's disease, lymphosarcoma, and chronic lymphocytic leukemia.

⑥. Connective tissue diseases: can be seen in rheumatoid arthritis, Still's disease, generalized scleroderma, dermatomyositis, and systemic lupus erythematosus.

⑦. Drug-induced melanin deposition: seen in long-term use of chloroquine or hydroxychloroquine, chlorpromazine, busulfan, nitrogen mustard, cyclophosphamide, arsenic, bismuth, lead, etc.