Low DHT

The various substances contained in the human body are within a stable range. If the value is lower or higher than this value, it may have an impact on the body. Dihydrotestosterone is the main hormone that promotes the secondary development of men, which can promote the development of the penis during the development period. What are the consequences of low dihydrotestosterone in the body? Let's read the following content to understand~

Dihydrotestosterone can be produced directly by the testicles, or it can be converted from androgens and estrogens as precursors by surrounding tissues. It can promote the normal development of the external genitalia and prostate, has a positive effect on the appearance and maintenance of secondary sexual characteristics, and promotes the maturation of sperm in the epididymis. In clinical practice, it is mainly used for abnormal sexual differentiation caused by 5α-reductase deficiency and for the identification and diagnosis of benign prostate diseases. It is also of great significance to observe the efficacy of prostate tumors, explore the causes of sexual dysfunction, infertility, and female hirsutism.

1. Clinical significance

1. Pathological increase

(1) Observation on the recovery of prostate cancer. There are reports that measuring the dihydrotestosterone content in prostate cancer tissue can be used to judge the postoperative effect. The higher the content in the tumor tissue, the longer the relief interval.

(2) Prostatic hypertrophy, hirsutism in women, polycystic ovary syndrome, and hyperthyroidism all increase in risk.

(3) Due to hypothalamic-pituitary dysfunction, the pituitary gland secretes increased progesterone. Continuous high levels of progesterone can stimulate the ovaries to secrete excessive dihydrotestosterone.

2. Pathological decrease

(1) Oligospermia, decreased sperm motility, and a significant decrease in the number of patients undergoing vasectomy

(2) The lichen sclerosus of the female vulva is reduced.

(3) Hypothyroidism, etc.

(4) Familial incomplete pseudohermaphroditism type II. This is an autosomal recessive genetic disease caused by severe deficiency or non-function of 5α-reductase. Testosterone cannot be converted into active dihydrotestosterone in the target organs, resulting in decreased serum dihydrotestosterone.

(5) Serum dihydrotestosterone may be reduced in men with sexual dysfunction caused by agenesis, cryptorchidism, 17α-hydroxylase deficiency, 3β-hydroxysteroid dehydrogenase deficiency, etc.

2. Reference Scope

Healthy adults: male 1.03 ~ 2.92nmoL/L; female 0.14 ~ 0.76nmol/L.

3. Dihydrotestosterone precautions

If the collected venous blood sample cannot be tested immediately, the serum or plasma should be frozen and stored.