What medicine should I take for male breast development?

Some men are surprised to find that their breasts have developed. Under normal circumstances, men will not develop breasts. If men develop breasts, it may be caused by too little male hormone secretion and too much female hormone secretion in the male body. At this time, men should take some measures to treat it in time. Otherwise, some female signs will appear. Let's learn what medicine men should take for breast development.

Commonly used drugs include the following:

1. Androgen preparations

① Testosterone: It has a good therapeutic effect on patients with testicular dysfunction. Commonly used is testosterone enanthate, which can increase the testosterone level in the body and is not converted into estradiol by aromatase. Generally, 200 mg is used, injected intramuscularly once every 3 to 4 weeks. Studies have reported that breasts shrank by 67% to 78% after 3 months of treatment. During the treatment period, plasma dihydrotestosterone increased, and LH, FSH, testosterone and estradiol levels were suppressed. They returned to normal after stopping the drug for 2 months. There was no recurrence of the disease after 6 to 15 months of follow-up observation. ② Dihydrotestosterone heptane salt: It acts directly on target cells, is not affected by aromatase, and has a better therapeutic effect.

2. Tamoxifen (Tamoxifen)

It is an estrogen antagonist that can bind to the ER of the target tissue and block the effect of estrogen. The usual dose is 20 mg per day orally. Some people report that the breasts are significantly reduced after taking the drug for one month. If the effect is not obvious, the dose can be appropriately increased. Literature reports that oral tamoxifen, 20 mg per day, for 3 consecutive months, partially regressed 80% of male breast development and completely regressed 60% of patients. Patients who responded to tamoxifen had reduced breast pain or tenderness within one month [22][23].

3. Clomiphene

It is an anti-estrogen drug with significant effects. It can reduce breast development in middle-aged people, but it can also cause breast development and has serious side effects. About 70% of patients have different degrees of efficacy when taken orally at a dose of 50-100 mg per day.

4. Aromatase inhibitors

① Testosterone lactone: It can block the conversion of testosterone into estradiol in the periphery. Some people use 450 mg per day, taken orally in divided doses, with good therapeutic effects and no adverse reactions. After taking the medicine, the level of androstenedione increased significantly, testosterone, dehydroepiandrosterone and E0 increased slightly, the androstenedione/E0 ratio increased, and there was no significant change in LH, PRL and E2 levels. ② Anastrazole: A new type of aromatase inhibitor, it has been used to treat postmenopausal breast cancer patients and has now been clinically proven to be safe and effective in treating male breast development. This drug inhibits tissue estrogen secretion, reduces estrogen production, and does not inhibit pituitary function. The dosage is 1 mg per day and gradually increased to 10 mg. Side effects include facial flushing, thinning hair, gastrointestinal reactions (anorexia, vomiting, diarrhea), etc.