Can Priligy and Viagra be used together?

Due to stress, lifestyle, daily diet and other reasons, most men suffer from impotence and premature ejaculation. Priligy can effectively treat premature ejaculation, and Viagra can treat impotence very well. So, is it okay to take Priligy and Viagra together? Let's find out about this question below.

The ingredient of Viagra is tadalafil. The physiological mechanism of penis erection involves the release of nitric oxide (NO) in the corpus cavernosum during the whole process of sexual arousal. NO activates guanylate cyclase, resulting in an increase in the level of cyclic guanosine ammonium sulfate (cGMP), which causes the smooth muscle in the corpus cavernosum to relax and blood to flow into it. Tadalafil has no direct relaxing effect on paraffin-sectioned human corpus cavernosum, but it can enhance the effect of nitric oxide (NO) by inhibiting phosphodiesterase type 5 (PDE5) that decomposes cGMP in the corpus cavernosum. When sexual arousal causes partial NO release, tadalafil inhibits PDE5 to increase the level of cGMP in the corpus cavernosum, relax the smooth muscle, and blood to flow into the corpus cavernosum. The highly recommended doses of tadalafil fail to work when there is no sexual arousal.

Priligy is a selective 5-5-hydroxytryptamine reuptake inhibitor (SSRI). 5-5-hydroxytryptamine (5-HT) is considered to be an important transmitter in the ejaculation process, and PE men have lower 5-HT levels. Priligy inhibits the reuptake of 5-HT by the pre-neuroneurotic nerves, increases the level of 5-HT in the neurotransmitter spaces, and inhibits the ejaculation reflex. Dapoxetine inhibits the reuptake of 5-HT by the pre-neuroneurotic nerves, increases the level of 5-HT in the neurotransmitter spaces, and inhibits the ejaculation reflex.

From the perspective of medicinal value, the mechanisms of action of Viagra and Priligy are different, and their actual effects are different. Viagra needs to be taken 30 minutes to 1 hour before sexual intercourse, and it can only be fully exerted under sexual arousal to assist in genital erection; while Priligy needs to be taken about 1 to 3 hours before sexual intercourse, and its main effect is to delay ejaculation. Therefore, in theory, Priligy and Viagra can be taken together, but it is best to do so under the specific guidance of a doctor or a technical professional.