Do you know what is the normal value of PSA?

Many people are not familiar with PSA. In fact, PSA stands for prostate-specific antigen, a medical term. Its normal value is related to human health, so people should have a certain understanding of it to better understand their physical condition. If any abnormality is found, they should seek medical treatment in time to better ensure their health.

1. Normal value of PSA

When the PSA levels of prostate hyperplasia and prostate cancer are between 4 and 10 ng/ml, they overlap to a large extent. In this so-called gray area, it is difficult to distinguish prostate hyperplasia and prostate cancer based on PSA levels. PSA can exist in the serum in free and bound forms. Free PSA refers to the part of PSA that is free in the plasma and not bound, expressed as fPSA; total serum PSA is expressed as tPSA. The fPSA concentration is lower in cancer patients than in benign hyperplasia patients. This difference is applied clinically to screen out early prostate cancer from patients with benign prostate hyperplasia. Currently, the fPSA/tPSA ratio is widely used to assist in distinguishing prostate cancer from benign hyperplasia. The reference value is 0.16, that is, if the ratio is <0.16, the possibility of prostate cancer is high. A low fPSA percentage indicates a higher likelihood of prostate cancer.

2. Serum PSA is a specific marker for prostate cancer

It is very meaningful for the diagnosis of early asymptomatic prostate cancer. Under normal circumstances, PSA is a serine protease secreted by prostate epithelial cells and is a glycoprotein that is directly secreted into the prostate duct system. Its normal function is to assist in the hydrolysis and liquefaction of semen clots, which is related to male fertility. There is a blood-epithelial barrier around the normal prostate duct system, which prevents PSA produced by the prostate epithelium from directly entering the blood, thereby maintaining a low concentration of PSA in the blood. It is generally believed that a serum PSA less than 4.0 ng/ml is normal, and a PSA greater than 10ng/ml increases the risk of prostate cancer.

Pay attention to your physical condition and see a doctor promptly.