Causes of sperm chromosome abnormalities in men

Chromosomal abnormalities are more likely to be passed on to the next generation, and sperm chromosomal abnormalities in men will affect the spermatogenesis of the male testicles, causing oligospermia or even azoospermia, leading to infertility. What are the causes of sperm chromosomal abnormalities in men?

Causes of Chromosomal Abnormalities

1. Long-term use of drugs by men will affect sperm quality and cause adverse effects on the fetus. For example, some common immunomodulators and other drugs have strong toxic effects and can directly disrupt the synthesis of sperm DNA, including changes in genetic material composition, chromosomal abnormalities and sperm deformities.

2. These drugs can also be discharged into the vagina along with the semen produced by the testicles through sexual intercourse, and enter the blood circulation after being absorbed by the vaginal mucosa, increasing the incidence of low birth weight and malformed fetuses and increasing the perinatal fetal mortality rate.

Men with abnormal chromosomes are not suitable for pregnancy. Abnormal chromosomes in men are related to the survival and development of offspring embryos. Eating more foods rich in folic acid can reduce the proportion of sperm with abnormal chromosomes. Among the sperm of a healthy man, 4% of sperm have abnormal chromosomes. Abnormal sperm chromosomes may lead to infertility, miscarriage and congenital idiocy in infants.