There is a granulation on the glans

What does it mean when a granulation grows on the glans? Many male friends will encounter this situation when taking a bath. Generally speaking, this granulation does not cause any pain, but it looks very unsightly. Andrologists tell everyone that this situation is likely to be caused by genital herpes. Generally speaking, genital herpes can be treated with systemic or local treatment methods.

In the clinical practice of STD hospitals, male genital herpes refers to herpes virus (Herpesviruses), which is a group of medium-sized double-stranded DNA viruses with more than 100 members. According to their physical and chemical properties, they are divided into three subfamilies: α, β, and γ. Alpha herpes virus (such as herpes simplex virus and varicella-zoster virus) proliferates rapidly and causes cell pathology. β herpes virus (such as giant cell virus) has a long growth cycle and infects cells to form giant cells. γ herpes virus, such as Epstein-Barr virus, infects lymphoid cells as target cells and can cause lymphoproliferation. Herpes virus has a wide range of hosts and can infect humans and other vertebrates. There are 7 herpes viruses that cause human production. Herpes virus mainly invades tissues of ectoderm origin, including skin, mucous membranes and nervous tissue. The infection sites and diseases caused are diverse, and there is a tendency for latent infection, which seriously threatens human health.

The disease is self-limiting and can be cured in about 1-2 weeks. The purpose of treatment is to prevent the next recurrence. There is no specific medicine for this disease so far. The principle of treatment is to shorten the course of the disease, prevent secondary infection, and reduce recurrence.

Systemic treatment

The treatment principle is to make the infected HSV inactive or even eliminate the virus; the second is to regulate immunity and prevent recurrence. Acyclovir can be taken intravenously or orally, Livzonvir can be taken orally, interferon can be injected intramuscularly, and interleukin II can be injected intramuscularly. The Chinese Academy of Sciences Microbiology Institute tested the vaginal wash containing PHMB and found that 99% of herpes viruses were killed within 3 minutes. In treatment, vaginal wash or disinfecting gel is used in combination with interleukin II, Levitra or Probabilin, and 95% of patients do not relapse.

1. Acyclovir (ACV):

It is recognized as the first choice drug. The usage method should be targeted at different GH situations.

(1) Initial GH: Oral administration of ACV 200 mg, 5 times a day for 7 consecutive days; or intravenous infusion of ACV 5 ml, 3 times a day for 5 to 7 consecutive days.

(2) Recurrent GH: Take ACV 200 mg orally 5 times a day; or lie down for 800 m twice a day for 5 consecutive days; if treatment is started at the onset of symptoms, some patients may not develop typical symptoms. When recurrences are frequent, take ACV 200 mg orally 3 times a day for 6 to 12 months.

(3) Immunosuppressed patients: For HIV-infected patients, GH is taken orally at a dose of 400 mg 3 to 5 times a day. If the condition is severe, 400 mg/kg is given by intravenous drip every 8 hours until recovery.

(4) Herpetic pruritus: Take ACV 200 mg orally, 5 times a day, for 7 to 10 days.

(5) HSV proctitis: Oral administration of ACV 400 mg, 5 times a day can shorten the course of the disease. For patients with immune damage or severe symptoms, intravenous infusion of ACV 5 mg/(kg·8h) can be used.

(6) Neonatal HSV: intravenous infusion of ACV 30 mg/(kg·d) or adenosine 30 mg/(kg·d) is usually used for 10-14 days.

2. Interferon (IFN)

Primary GH: intramuscular or subcutaneous injection, 1 million U to 3 million U for adults, 50,000 U/(kg·d) for children, 1 week to 2 weeks.

Recurrent GH: intramuscular or subcutaneous injection, 3 million U-6 million U for adults, 100,000 U/(kg'

3. Virus inhibitor (triazole): inhibits the replication and synthesis of DNA and RNA of many pathogens.

(l) Primary GH and AIDS combined with HSV infection: intramuscular injection of 15 mg/(kg·d).

(2) Relapse GH: Oral administration of 0.49 g, 4 times a day. After 3 days, change to 0.4 g, 2 times a day, for a total of 12 days.

4. Sodium foscarnet: selectively inhibits DNA-dependent DNA polymerase induced by chlamydia. Intravenous drip of 40mg-60mg, once every 8 hours, for 4 consecutive days. Only used for individual severe GH, especially caused by acyclovir-resistant HSV strains. Side effects include renal toxicity and calcium-phosphate metabolism disorders.

(5) Indomethacin: Oral, 25 minutes lying down, 3 times a day.

(6) Chromosome polymyxin B: intramuscular injection, 2 mg, 2 to 3 times a week.

(7) gD-2 vaccine: It is the expression of recombinant HSV-2 glycoprotein in CHO cells, which induces the production of specific antibodies and neutralizing antibodies, which are equivalent to or exceed the level produced by GH patients. Vaccinate gD-2 100-9, and repeat once after 2 months. Compared with the control group, the recurrence rate is significantly reduced. The gD-2 vaccine can reduce symptoms and prevent infection.

(8) Monoclonal antibody therapy is a promising new approach. HSV glycoprotein vaccine and recombinant subunit vaccine induce the body to produce antibodies and enhance cellular functions, which are effective in eliminating latent HSV infection, initial attacks, and recurrences.

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