What exactly causes anti-sperm antibody positivity?

In recent years, due to factors such as excessive stress in life and overwork, more and more urban people have suffered from immune infertility. Among infertility patients, most men and women cannot have babies because of anti-sperm and anti-body positivity. The harm it causes to many couples who want to have children is self-evident, so what is it? The following editor will introduce its causes in detail to help patients treat the disease in time.

The presence of antisperm antibodies prevents sperm from penetrating the cervical mucus and fertilization. If the cervical mucus of these women is taken for observation after sexual intercourse, it will be found that the number of active sperm in it is lower than normal. The cervical mucus prevents the sperm from moving forward, resulting in infertility.

Causes of male anti-sperm antibody positivity include:

1. Some experts say that the cause of male anti-sperm antibodies may be due to vas deferens inflammation and some vas deferens blockages, as well as sperm spillage that causes sperm to come into contact with the body's immune system, thereby producing anti-sperm antibodies.

2. If there are factors such as trauma or radiation damage, sperm will come into contact with the immune system, which will produce antibodies, inhibit sperm activity, and become dead sperm. Sperm problems will affect fertility.

3. There are immunosuppressive factors in seminal plasma, which inhibit the normal functions of T and B cells. They can also cover the surface of sperm, making the female immune system unable to respond to sperm.

4. After the sperm enters the female vagina, a layer of maternal protein will quickly cover the surface of the sperm to protect the sperm and help it move upward.

5. The enzymes present in seminal plasma can affect the expression of sperm surface antigens.

6. Only a few sperms in the ejaculated semen enter the uterine cavity. Therefore, normal women rarely produce anti-sperm antibodies.

Through the above knowledge, we know that anti-sperm and anti-body positivity is very harmful to reproductive health. However, many patients often ignore their symptoms, resulting in the disease not being treated in time and fertility being damaged. Therefore, it is very necessary to have some reproductive knowledge. If patients find the above symptoms, they should go to an infertility hospital as soon as possible for detailed examination and treatment.