What are the causes of gynecological polycystic ovary syndrome?

Nowadays, many women suffer from polycystic ovary syndrome. This disease is mainly caused by the fact that people do not know much about it, which leads to them suffering from this disease. It is very harmful to women. If you want to avoid the occurrence of this disease, you must not only take preventive measures in time, but also be clear about the factors that induce this disease. Only in this way can you better prevent and treat this disease.

(I) Hypothalamic pituitary dysfunction PCOS patients have high LH levels and normal or low FSH levels, so the LH/FSH ratio is greater than 3. LH has a strong effect on the synthesis of luteinizing hormone-releasing hormone (LH-

The response of RH) increases, so hypothalamic-pituitary dysfunction is considered to be the initiating factor of this syndrome, which leads to abnormal synthesis of steroid hormones in the ovaries and causes chronic anovulation. The increase in LH level not only increases the pulse amplitude, but also increases the frequency. This may be due to excessive peripheral androgens, which are converted into excessive androgens by aromatase and continue to interfere with the function of the hypothalamus-pituitary gland.

(II) Abnormal adrenal cortex function Some PCOS patients have increased adrenal gland secretion of androgen, which may be due to the abnormal regulation of the adrenal cortex P450c17 enzyme complex, resulting in the lack of enzyme blockage in the biosynthesis of steroid hormones from 17-hydroxyprogesterone to estrone. Abnormal adrenal function can affect the abnormal relationship and secretion of the hypothalamus-pituitary-ovarian axis.

(III) Abnormal ovarian autocrine and paracrine regulation mechanisms Most scholars currently speculate that there are certain substances in the follicles of PCOS patients, such as epidermal growth factor (EGF), transforming growth factor

a (TGFa) and inhibin, etc., inhibit the sensitivity of granulocytes to FSH, increase the FSH threshold, and thus hinder the selection and further development of dominant follicles. That is, the abnormality of the local autocrine and paracrine regulatory mechanism of the ovary, which hinders the selection of dominant follicles, is the cause of PCOS.

I believe everyone now understands what causes polycystic ovary syndrome. Among them, galactorrhea is also the main cause of the syndrome, and this disease is usually hereditary. No matter which factor causes this disease, it can be completely cured as long as it is actively treated.